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Chemical Characterization and Antiplatelet Potential of Bioactive Extract from Tomato Pomace (Byproduct of Tomato Paste).

Thematic Task Force on Healthy Aging, CUECH Research Network, Universidad de Talca, Talca 3460000, Chile. ipalomo@utalca.cl. Interdisciplinary Center on Aging, Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Talca 3460000, Chile. ipalomo@utalca.cl. Centro de Estudios en Alimentos Procesados (CEAP), CONCIYT, Gore Maule, Talca 3460000, Chile. ipalomo@utalca.cl. Centro de Estudios en Alimentos Procesados (CEAP), CONCIYT, Gore Maule, Talca 3460000, Chile. aconcha@ceap.cl. Faculty of Agricultural Sciences, Universidad de Talca, Talca 3460000, Chile. aconcha@ceap.cl. Thematic Task Force on Healthy Aging, CUECH Research Network, Universidad de Talca, Talca 3460000, Chile. mariane.lutz@uv.cl. Interdisciplinary Center for Health Studies, CIESAL, Faculty of Medicine, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2650000, Chile. mariane.lutz@uv.cl. Centro de Estudios en Alimentos Procesados (CEAP), CONCIYT, Gore Maule, Talca 3460000, Chile. macarenasaid@gmail.com. Centro de Estudios en Alimentos Procesados (CEAP), CONCIYT, Gore Maule, Talca 3460000, Chile. bsaez@ceap.cl. Faculty of Health Sciences, School of Nursing, Universidad de Talca, Talca 3460000, Chile. advasquez@utalca.cl. Thematic Task Force on Healthy Aging, CUECH Research Network, Universidad de Talca, Talca 3460000, Chile. edfuentes@utalca.cl. Interdisciplinary Center on Aging, Thrombosis Research Center, Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Universidad de Talca, Talca 3460000, Chile. edfuentes@utalca.cl. Centro de Estudios en Alimentos Procesados (CEAP), CONCIYT, Gore Maule, Talca 3460000, Chile. edfuentes@utalca.cl.

Nutrients. 2019;(2)
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Abstract

We examined the ability of tomato pomace extract (by-product) to affect platelet aggregation in healthy humans (clinical pilot study). In phase 1 the tolerance of participants (n = 15; 5 per dose level) ingesting tomato pomace extract across three dose levels (1, 2.5, and 10 g) was evaluated. Phase 2 was a single-blind, placebo-controlled, parallel design human (male, n = 99; 33 per group) pilot intervention trial investigating the acute and repeated dose effects (5 days) of different doses of tomato pomace extract (1 g, 2.5 g or placebo) on platelet aggregation ex vivo. Various flavonoids (coumaric acid, floridzin, floretin, procyanidin B₂, luteolin-7-O-glucoside, kaempferol, and quercitin) and nucleosides (adenosine, inosine, and guanosine) were identified in the tomato pomace extract. The clinical study showed that the daily consumption of 1 g of aqueous extract of tomato pomace for 5 days exerted an inhibitory activity on platelet aggregation.

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Publication Type : Randomized Controlled Trial

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